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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
2.42
Human Site:
T75
Identified Species:
4.1
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
T75
L
E
A
K
K
L
D
T
A
P
E
K
F
S
K
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
M75
L
E
A
K
K
L
D
M
A
P
E
K
F
S
K
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
L75
L
E
A
K
K
L
D
L
A
P
E
K
F
S
K
Dog
Lupus familis
XP_534917
565
65190
M123
L
E
A
E
K
L
H
M
T
P
E
K
F
N
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
V190
L
E
A
K
K
L
N
V
V
P
E
K
F
S
K
Rat
Rattus norvegicus
Q4V8A3
586
65492
G179
P
N
A
K
K
R
Q
G
V
I
G
G
P
N
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
V72
H
R
P
R
P
H
K
V
P
L
T
G
T
G
V
Chicken
Gallus gallus
Q5ZIU3
526
59419
G118
P
N
A
K
K
R
Q
G
V
I
G
G
P
N
N
Frog
Xenopus laevis
Q2TAE3
750
84138
S119
Q
Q
G
Q
G
D
D
S
S
H
K
K
E
R
K
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
G183
L
D
T
K
K
I
E
G
S
Q
G
S
P
Q
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
A169
S
K
N
Y
N
K
P
A
P
T
A
N
T
T
N
Honey Bee
Apis mellifera
XP_396369
614
68978
G152
L
S
A
T
K
I
H
G
E
E
G
S
S
Q
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
G340
V
L
T
K
P
S
E
G
K
C
N
N
G
F
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
93.3
93.3
66.6
N.A.
80
20
N.A.
0
20
20
20
N.A.
0
20
N.A.
N.A.
P-Site Similarity:
100
93.3
93.3
80
N.A.
86.6
26.6
N.A.
6.6
26.6
53.3
46.6
N.A.
13.3
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
58
0
0
0
0
8
22
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
8
29
0
0
0
0
0
0
0
8
% D
% Glu:
0
36
0
8
0
0
15
0
8
8
36
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
36
8
0
% F
% Gly:
0
0
8
0
8
0
0
36
0
0
29
22
8
8
0
% G
% His:
8
0
0
0
0
8
15
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
15
0
0
0
15
0
0
0
0
0
% I
% Lys:
0
8
0
58
65
8
8
0
8
0
8
43
0
0
43
% K
% Leu:
50
8
0
0
0
36
0
8
0
8
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
15
0
0
0
0
0
0
0
% M
% Asn:
0
15
8
0
8
0
8
0
0
0
8
15
0
22
36
% N
% Pro:
15
0
8
0
15
0
8
0
15
36
0
0
22
0
0
% P
% Gln:
8
8
0
8
0
0
15
0
0
8
0
0
0
15
0
% Q
% Arg:
0
8
0
8
0
15
0
0
0
0
0
0
0
8
0
% R
% Ser:
8
8
0
0
0
8
0
8
15
0
0
15
8
29
0
% S
% Thr:
0
0
15
8
0
0
0
8
8
8
8
0
15
8
0
% T
% Val:
8
0
0
0
0
0
0
15
22
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _